8-Nitroguanine

8-Nitroguanine, a product of nitrative DNA damage caused by reactive nitrogen species, is a potential biomarker for progression of malignant fibrous histiocytoma[1][2].

Product Specifications

CAS Number

[168701-80-2]

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

NO Synthase

Type

Reference compound

Related Pathways

Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Infection; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/8-nitroguanine.html

Solubility

10 mM in DMSO

Smiles

O=C1N=C(N)NC2=C1NC([N+]([O-])=O)=N2

Molecular Formula

C5H4N6O3

Molecular Weight

196.12

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362-P405-P501

References & Citations

[1]Hiroshi Ohshima, et al. 8-nitroguanine, a product of nitrative DNA damage caused by reactive nitrogen species: formation, occurrence, and implications in inflammation and carcinogenesis. Antioxid Redox Signal. 2006 May-Jun;8 (5-6) :1033-45.|[2]Yoko Hoki, et al. 8-Nitroguanine as a potential biomarker for progression of malignant fibrous histiocytoma, a model of inflammation-related cancer. Oncol Rep. 2007 Nov;18 (5) :1165-9.|[3]Yusuke Hiraku, et al. Formation of 8-nitroguanine, a nitrative DNA lesion, in inflammation-related carcinogenesis and its significance. Environ Health Prev Med. 2010 Mar;15 (2) :63-72.