TBE56

TBE56 is a molecular glue serving as a BACH1 degrader, with an EC50 of 44 nM. It is a weak NRF2 inducer and is the biotinylated form of TBE31. TBE56 interacts with BACH1 via an E3 ligase FBX022-mediated mechanism to promote its degradation. It reduces Fe2+ accumulation, ROS generation, and malondialdehyde (MDA) levels in bone marrow mesenchymal stem cells (BMSCs) overexpressing Prominin-2, while increasing the GSH/GSSG ratio and upregulating GPX4. In a puncture-induced spinal disc degeneration (IVDD) model in SD rats, TBE56 significantly improves disc degeneration, making it useful for studying IVDD.

Product Specifications

CAS Number

1459836-79-3

Smiles

C (#C) [C@@]12C ([C@@]3 (C) [C@] (CC1) ([C@] (COC (CCCCCNC (CCCC[C@H]4[C@@]5 ([C@] (CS4) (NC (=O) N5) [H]) [H]) =O) =O) (C) C (=O) C (C#N) =C3) [H]) =CC (=O) C (C#N) =C2