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SKLB-0124

SKLB-0124 is a potent degrader of PRMT6, exhibiting DC50 values of 15.4 μM in HCC827 cells and 16.4 μM in MDA-MB-435 cells. It does not degrade PRMT1 or PRMT8. SKLB-0124 has an IC50 value of 1.6 μM for PRMT6. It induces proteasome-dependent degradation of PRMT6 and significantly inhibits cell proliferation. Additionally, SKLB-0124 effectively induces apoptosis and cell cycle arrest, making it suitable for research in lung cancer and breast cancer.

Product Specifications

CAS Number

3065966-31-3

Smiles

O=C (NC1=CC=C (C=C1) C=2C=NC=C (C2) CN (C) CCNC) CCCNC (=O) CC34CC5CC (CC (C5) C3) C4

Molecular Formula

C32H45N5O2

Molecular Weight

531.75

Notes

For research use only.

Available Sizes

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