HIPS probe-1

HIPS probe-1 (Compound 1) is a click chemistry reagent containing an alkyne group. It undergoes copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules. Serving as a chemical probe, HIPS probe-1 specifically identifies and labels aldehyde functional groups in DNA, particularly at abasic sites (AP sites), for DNA damage research.