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Ilacirnon

CCX140 (CCX140-B) is a potent CCR2 antagonist.

Product Specifications

CAS Number

1100318-47-5

Product Name Alternative

CCX140; CCX140-B

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

CCR

Type

Reference compound

Related Pathways

GPCR/G Protein; Immunology/Inflammation

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease; Endocrinology

Assay Protocol

https://www.medchemexpress.com/CCX140.html

Purity

98.05

Solubility

DMSO : ≥ 100 mg/mL|H2O : 0.25 mg/mL (ultrasonic; warming)

Smiles

FC(F)(F)C1=CC(S(=O)(NC2=CC(C)=CN=C2C(C3=NC=NC4=C3C=CN4)=O)=O)=CC=C1Cl

Molecular Formula

C20H13ClF3N5O3S

Molecular Weight

495.86

Precautions

H302, H315, H319, H335

References & Citations

[1]Sullivan T, et al. CCR2 antagonist CCX140-B provides renal and glycemic benefits in diabetic transgenic human CCR2 knockin mice. Am J Physiol Renal Physiol. 2013 Nov 1;305 (9) :F1288-97.|[2]Sullivan TJ, et al. Experimental evidence for the use of CCR2 antagonists in the treatment of type 2 diabetes. Metabolism. 2013 Nov;62 (11) :1623-32.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

Phase 2

Isoform

CCR2; CCR5

Available Sizes

Frequently Asked Questions

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