Ilacirnon
CCX140 (CCX140-B) is a potent CCR2 antagonist.
Product Specifications
CAS Number
1100318-47-5
Product Name Alternative
CCX140; CCX140-B
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
CCR
Type
Reference compound
Related Pathways
GPCR/G Protein; Immunology/Inflammation
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease; Endocrinology
Assay Protocol
https://www.medchemexpress.com/CCX140.html
Purity
98.05
Solubility
DMSO : ≥ 100 mg/mL|H2O : 0.25 mg/mL (ultrasonic; warming)
Smiles
FC(F)(F)C1=CC(S(=O)(NC2=CC(C)=CN=C2C(C3=NC=NC4=C3C=CN4)=O)=O)=CC=C1Cl
Molecular Formula
C20H13ClF3N5O3S
Molecular Weight
495.86
Precautions
H302, H315, H319, H335
References & Citations
[1]Sullivan T, et al. CCR2 antagonist CCX140-B provides renal and glycemic benefits in diabetic transgenic human CCR2 knockin mice. Am J Physiol Renal Physiol. 2013 Nov 1;305 (9) :F1288-97.|[2]Sullivan TJ, et al. Experimental evidence for the use of CCR2 antagonists in the treatment of type 2 diabetes. Metabolism. 2013 Nov;62 (11) :1623-32.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
CCR2; CCR5
Available Sizes
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