Inosine-5'-diphosphoric acid disodium salt

Inosine-5'-diphosphoric acid disodium salt, as a decoy substrate for NM23-H2, exhibits excellent binding ability at the GDP-binding site of NM23-H2 with a dissociation constant (KD) of 5.0 μM. It can inhibit c-MYC transcription by disrupting the interaction between NM23-H2-Pu27-GQ, thereby inducing apoptosis and G2/M cell cycle arrest without affecting the kinase activity mediated by NM23-H2. Inosine-5'-diphosphoric acid disodium salt also possesses anti-hypoxic, antihypertensive, and antiarrhythmic activities, protects organisms from γ-radiation damage, and can be used in research on cancers such as Burkitt lymphoma and cardiovascular diseases.