CHIR-98023

CHIR-98023 is a potent, selective and reversible inhibitor of GSK3, with IC50s of 10 nM and 6.7 nM for GSK3α and GSK3β, respectively. CHIR-98023 can improve insulin action and glucose metabolism[1][2].

Product Specifications

CAS Number

[252916-76-0]

UNSPSC

12352005

Target

GSK-3

Type

Reference compound

Related Pathways

PI3K/Akt/mTOR; Stem Cell/Wnt

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/chir-98023.html

Solubility

10 mM in DMSO

Smiles

O=[N+](C1=CN=C(NCCNC2=NC=C(C3=NC=CN3)C(C4=CC=C(Cl)C=C4Cl)=N2)C=C1)[O-]

Molecular Formula

C20H16Cl2N8O2

Molecular Weight

471.30

References & Citations

[1]Cline GW, et, al. Effects of a novel glycogen synthase kinase-3 inhibitor on insulin-stimulated glucose metabolism in Zucker diabetic fatty (fa/fa) rats. Diabetes. 2002 Oct;51 (10) :2903-10.|[2]Hu M, et, al. Role of GSK-3beta activation and alpha7 nAChRs in Abeta (1-42) -induced tau phosphorylation in PC12 cells. J Neurochem. 2008 Aug;106 (3) :1371-7.