PROTAC KDM3 degrader-1
PROTAC KDM3 degrader-1 (Compound 4) is a CRBN-recruiting PROTAC designed based on the IOX1 scaffold. PROTAC KDM3 degrader-1 selectively degrades the KDM3A and KDM3B proteins, thereby inhibiting the Wnt/β-catenin signaling pathway. PROTAC KDM3 degrader-1 significantly suppresses the self-renewal capacity of colorectal cancer stem cells and inhibits the growth of colorectal cancer tumors. PROTAC KDM3 degrader-1 is suitable for research on colorectal cancer (Target protein ligand (Pink) : HY-12304; linker (Black) : HY-22335; Conjugate of E3 ligase ligand and linker: HY-112599; E3 ligase (Blue) : HY-41547).
Product Specifications
UNSPSC
12352211
Target
Histone Demethylase; PROTACs; Wnt; β-catenin
Type
Reference compound
Related Pathways
Epigenetics; PROTAC; Stem Cell/Wnt
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/wnt-β-catenin-in-5.html
Concentration
10mM
Purity
99.07
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(C1=C2C=CC=NC2=C(O)C=C1)NCCOCCOCCOCCOCCNC3=CC=CC(C(N4C(CC5)C(NC5=O)=O)=O)=C3C4=O
Molecular Formula
C33H37N5O10
Molecular Weight
663.67
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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