PROTAC KDM3 degrader-1
PROTAC KDM3 degrader-1 (Compound 4) is a CRBN-recruiting PROTAC designed based on the IOX1 scaffold. PROTAC KDM3 degrader-1 selectively degrades the KDM3A and KDM3B proteins, thereby inhibiting the Wnt/β-catenin signaling pathway. PROTAC KDM3 degrader-1 significantly suppresses the self-renewal capacity of colorectal cancer stem cells and inhibits the growth of colorectal cancer tumors. PROTAC KDM3 degrader-1 is suitable for research on colorectal cancer (Target protein ligand (Pink) : HY-12304; linker (Black) : HY-22335; Conjugate of E3 ligase ligand and linker: HY-112599; E3 ligase (Blue) : HY-41547).
Product Specifications
UNSPSC
12352211
Target
Histone Demethylase; PROTACs; Wnt; β-catenin
Type
Reference compound
Related Pathways
Epigenetics; PROTAC; Stem Cell/Wnt
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/wnt-β-catenin-in-5.html
Concentration
10mM
Purity
99.07
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(C1=C2C=CC=NC2=C(O)C=C1)NCCOCCOCCOCCOCCNC3=CC=CC(C(N4C(CC5)C(NC5=O)=O)=O)=C3C4=O
Molecular Formula
C33H37N5O10
Molecular Weight
663.67
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
Explore Other Products
Browse additional items from our catalog
CD86 (Dendritic Cells Maturation Marker) (rC86/1146), CF647 conjugate, 0.1mg/mL
Rabbit IgG (H&L) Antibody ATTO 647N Conjugated Pre-Adsorbed
