PROTAC KDM3 degrader-1

PROTAC KDM3 degrader-1 (Compound 4) is a CRBN-recruiting PROTAC designed based on the IOX1 (HY-12304) scaffold. PROTAC KDM3 degrader-1 selectively degrades the KDM3A and KDM3B proteins, thereby inhibiting the Wnt/β-catenin signaling pathway. PROTAC KDM3 degrader-1 significantly suppresses the self-renewal capacity of colorectal cancer stem cells and inhibits the growth of colorectal cancer tumors. PROTAC KDM3 degrader-1 is suitable for research on colorectal cancer (Target protein ligand (Pink) : HY-12304; linker (Black) : HY-22335; Conjugate of E3 ligase ligand and linker: HY-112599; E3 ligase (Blue) : HY-41547) [1].

Product Specifications

UNSPSC

12352211

Target

Histone Demethylase; PROTACs; Wnt; β-catenin

Type

Reference compound

Related Pathways

Epigenetics; PROTAC; Stem Cell/Wnt

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/wnt-β-catenin-in-5.html

Concentration

10mM

Purity

99.07

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(C1=C2C=CC=NC2=C(O)C=C1)NCCOCCOCCOCCOCCNC3=CC=CC(C(N4C(CC5)C(NC5=O)=O)=O)=C3C4=O

Molecular Formula

C33H37N5O10

Molecular Weight

663.67

References & Citations

[1]Zaman S U, et al. Novel PROTAC probes targeting KDM3 degradation to eliminate colorectal cancer stem cells through inhibition of Wnt/β-catenin signaling[J]. RSC Medicinal Chemistry, 2024.