(-) -Aspartic acid

(-) -Aspartic acid is a pyroptosis inhibitor. (-) -Aspartic acid acts as a neurotransmitter and neuromodulator, participates in hormone synthesis and regulation, and plays a role in nervous system development and endocrine system[5].

Product Specifications

CAS Number

[1783-96-6]

Product Name Alternative

(R) -Aspartic acid; D- (-) -Aspartic acid

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H335

Target

Pyroptosis

Type

Natural Products

Related Pathways

Apoptosis; Immunology/Inflammation

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/_-_-Aspartic_acid.html

Purity

98.0

Solubility

DMSO : < 1 mg/mL|H2O : 66.67 mg/mL (ultrasonic; adjust pH to 7 with 1M NaOH)

Smiles

N[C@@H](C(O)=O)CC(O)=O

Molecular Formula

C4H7NO4

Molecular Weight

133.10

Precautions

H302, H315, H319, H335

References & Citations

[1]Xuechun Du, et al. D-aspartic acid protects against gingival fbroblasts infammation by suppressing pyroptosis. Mol Biol Rep. 2022 Jul;49 (7) :5821-5829.|[2]Di Nisio A, et al. D-Aspartic acid stimulates steroidogenesis through the delay of LH receptor internalization in a mammalian Leydig cell line. J Endocrinol Invest. 2016 Feb;39 (2) :207-213. |[3]D'Aniello A, et al. Involvement of D-aspartic acid in the synthesis of testosterone in rat testes. Life Sci. 1996;59 (2) :97-104. |[4]D'Aniello A, et al. Occurrence of D-aspartic acid and N-methyl-D-aspartic acid in rat neuroendocrine tissues and their role in the modulation of luteinizing hormone and growth hormone release. FASEB J. 2000 Apr;14 (5) :699-714. |[5]D'Aniello A. D-Aspartic acid: an endogenous amino acid with an important neuroendocrine role. Brain Res Rev. 2007 Feb;53 (2) :215-34.