Pridopidine (hydrochloride)
Pridopidine (ACR16) hydrochloride, a dopamine (DA) stabilizer, acts as a low affinity dopamine D2 receptor (D2R) antagonist. Pridopidine exerts high affinity towards sigma 1 receptor (S1R) with Ki between 70 and 80 nM, which is ~100-fold higher than its affinity toward D2R.
Product Specifications
CAS Number
882737-42-0
Product Name Alternative
ACR16 (hydrochloride) ; ASP2314 (hydrochloride) ; FR310826 (hydrochloride)
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
Dopamine Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/pridopidine-hydrochloride.html
Smiles
O=S(C1=CC(C2CCN(CC2)CCC)=CC=C1)(C)=O.Cl
Molecular Formula
C15H24ClNO2S
Molecular Weight
317.87
Precautions
P261-P280-P302+P352
References & Citations
[1]Geva M, et al. Pridopidine activates neuroprotective pathways impaired in Huntington Disease. Hum Mol Genet. 2016 Sep 15;25 (18) :3975-3987.|[2]Squitieri F, et al. Pridopidine, a dopamine stabilizer, improves motor performance and shows neuroprotective effects in Huntington disease R6/2 mouse J Cell Mol Med. 2015 Nov;19 (11) :2540-8. model.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 3
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