Hancockiamide A

Hancockiamide A, an N-cinnamoylated piperazine fungal metabolite identified in A. hancockii, exhibits antibacterial and anticancer properties. It is effective against B. subtilis with a minimum inhibitory concentration (MIC) of 50 μg/ml. Additionally, Hancockiamide A is cytotoxic to NS-1 murine myeloma cells with an MIC of 3.1 μg/ml, while showing no toxicity to neonatal foreskin fibroblasts at 100 μg/ml.