Mollicellin K

Mollicellin K is a benzophenone derivative isolated from Chaetomium brasiliense. It exhibits antibacterial activity against Mycobacterium tuberculosis, antimalarial activity against Plasmodium falciparum (IC50 = 1.2 μM), and antifungal activity against Candida albicans (IC50 = 1.2 μM) . Additionally, Mollicellin K demonstrates cytotoxicity towards KB cells (IC50 = 1.9 μM), BC1 cells (IC50 = 6.8 μM), NCI-H187 cells (IC50 = 0.35 μM), and five cholangiocarcinoma cell lines. The minimum inhibitory concentration (MIC) for tuberculosis is 12.5 μM.