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Sordarin

Sordarin (Compound 1) is an antifungal agent that targets elongation factor 2 (EF2) and features a tetracyclic diterpene core with a norbornene system. It can be isolated from the fungus Sordaria araneosa. Sordarin exhibits potent antifungal activity against Saccharomyces cerevisiae and Candida albicans. By stabilizing the ribosome/EF2 complex, Sordarin blocks ribosomal translocation along mRNA during nascent polypeptide chain elongation, thereby inhibiting fungal protein synthesis.

Product Specifications

CAS Number

11076-17-8

Smiles

C (O) (=O) [C@]12[C@@]3 (CO[C@H]4[C@@H] (O) [C@H] (O) [C@H] (OC) [C@@H] (C) O4) [C@] (C[C@]1 (C=O) [C@]5 ([C@] (C3) ([C@H] (C) CC5) [H]) [H]) (C=C2C (C) C) [H]

Molecular Formula

C27H40O8

Molecular Weight

492.61

Notes

For research use only.

Available Sizes

Frequently Asked Questions

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