Cinnamtannin D1
Cinnamtannin D1 is an orally active polyphenolic compound that modulates the Th17/Treg cell balance by inhibiting AHR expression. It reduces apoptosis and ROS in INS-1 cells and primary cultured mouse islets induced by Palmitic acid (PA) . Cinnamtannin D1 mitigates Th17 cell differentiation by downregulating p-STAT3/RORγt and enhances Treg cell differentiation by upregulating p-STAT5/Foxp3. In a collagen-induced arthritis (CIA) mouse model, it demonstrates excellent anti-arthritic efficacy. Cinnamtannin D1 is applicable for rheumatoid arthritis (RA) research.
Product Specifications
CAS Number
97233-06-2
Smiles
O[C@H]1[C@@]2 (OC3=C ([C@]1 (C=4C (O2) =CC (O) =CC4O) [H]) C5=C (C (O) =C3) [C@@H] ([C@@H] (O) [C@H] (O5) C6=CC (O) =C (O) C=C6) C7=C8C (C[C@H] (O) [C@H] (O8) C9=CC (O) =C (O) C=C9) =C (O) C=C7O) C%10=CC (O) =C (O) C=C%10
Molecular Formula
C45H36O18
Molecular Weight
864.77
Notes
For research use only.
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