ML213

ML213 is a selective activator of Kv7.2 and Kv7.4 channels, enhances Kv7.2 and Kv7.4 channels with EC50s of 230 and 510 nM, respectively.

Product Specifications

CAS Number

[489402-47-3]

UNSPSC

12352005

Hazard Statement

H315, H319, H335, H413

Target

Potassium Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/ML213.html

Purity

99.76

Solubility

DMSO : 36.67 mg/mL (ultrasonic)

Smiles

O=C(C1C(C2)CCC2C1)NC3=C(C)C=C(C)C=C3C

Molecular Formula

C17H23NO

Molecular Weight

257.37

Precautions

H315, H319, H335, H413

References & Citations

[1]Brueggemann LI, et al. Differential activation of vascular smooth muscle Kv7.4, Kv7.5, and Kv7.4/7.5 channels by ML213 and ICA-069673. Mol Pharmacol. 2014 Sep;86 (3) :330-41.|[2]Jepps TA, et al. Vasorelaxant effects of novel Kv 7.4 channel enhancers ML213 and NS15370. Br J Pharmacol. 2014 Oct;171 (19) :4413-24.|[3]Yu H, et al. Discovery, Synthesis, and Structure Activity Relationship of a Series of N-Aryl- bicyclo[2.2.1]heptane-2-carboxamides: Characterization of ML213 as a Novel KCNQ2 and KCNQ4 Potassium Channel Opener. ACS Chem Neurosci. 2011 Oct 19;2 (10) :572-577.