Apinocaltamide
Apinocaltamide (ACT-709478) is a potent, selective, orally active, and brain penetrating T-type calcium channel blocker. ACT-709478 is used in the research of generalized epilepsies[1].
Product Specifications
CAS Number
[1838651-58-3]
Product Name Alternative
ACT-709478
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Calcium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/apinocaltamide.html
Purity
99.83
Solubility
DMSO : ≥ 125 mg/mL
Smiles
O=C(NC1=NN(CC2=NC=C(C#N)C=C2)C=C1)CC3=CC=C(C4(C(F)(F)F)CC4)C=C3
Molecular Formula
C22H18F3N5O
Molecular Weight
425.41
Precautions
H302, H315, H319, H335
References & Citations
[1]Bezençon O, et al. Discovery of a Potent, Selective T-type Calcium Channel Blocker as a Drug Candidate for the Treatment of Generalized Epilepsies. J Med Chem. 2017 Dec 14;60 (23) :9769-9789.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
L-type calcium channel; T-type calcium channel
Available Sizes
Curated Selection
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