NSD2-PWWP1 ligand 1
Product Specifications
UNSPSC Description
NSD2-PWWP1 ligand 1 (compound 34) is a small molecule ligand targeting the NSD2-PWWP1 domain (pIC50: 8.2). NSD2 is a large multidomain protein with histone writer and histone reader functions. Dysregulation of the levels of histone methyltransferase nuclear receptor binding SET domain 2 (NSD2) may lead to a variety of hematological and solid malignancies. NSD2-PWWP1 ligand 1 binds to NSD2, reducing its enzymatic activity and inhibiting tumorigenesis[1].
Target Antigen
Histone Methyltransferase
Type
Reference compound
Related Pathways
Epigenetics
Applications
Cancer-programmed cell death
Field of Research
cancer
Assay Protocol
https://www.medchemexpress.com/nsd2-pwwp1-ligand-1.html
Smiles
CC1=CC=C(C=C1C2=NOC(C)=C2C3=CC4=C(NC(CO4)=O)C=C3)CN5CCCCC5
Molecular Weight
417.50
References & Citations
[1]Carlino L, et al. Identification of Novel Potent NSD2-PWWP1 Ligands Using Structure-Based Design and Computational Approaches. J Med Chem. 2024 Jun 13;67(11):8962-8987.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-161670/NSD2-PWWP1-ligand-1-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-161670/
Clinical Information
No Development Reported
Curated Selection
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