NSD2-PWWP1 ligand 1

NSD2-PWWP1 ligand 1 (compound 34) is a small molecule ligand targeting the NSD2-PWWP1 domain (pIC50: 8.2) . NSD2 is a large multidomain protein with histone writer and histone reader functions. Dysregulation of the levels of histone methyltransferase nuclear receptor binding SET domain 2 (NSD2) may lead to a variety of hematological and solid malignancies. NSD2-PWWP1 ligand 1 binds to NSD2, reducing its enzymatic activity and inhibiting tumorigenesis[1].

Product Specifications

UNSPSC

12352005

Target

Histone Methyltransferase

Type

Reference compound

Related Pathways

Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/nsd2-pwwp1-ligand-1.html

Smiles

CC1=CC=C(C=C1C2=NOC(C)=C2C3=CC4=C(NC(CO4)=O)C=C3)CN5CCCCC5

Molecular Formula

C25H27N3O3

Molecular Weight

417.50

References & Citations

[1]Carlino L, et al. Identification of Novel Potent NSD2-PWWP1 Ligands Using Structure-Based Design and Computational Approaches. J Med Chem. 2024 Jun 13;67 (11) :8962-8987.