RORγt Inverse agonist 3
RORγt Inverse agonist 3 is a potent, selective and orally active RORγ inverse agonist, with EC50s of 0.22 μM and 0.15 μM for hRORγ and RORγt (human IL-17 cells), respectively[1].
Product Specifications
CAS Number
[2364429-77-4]
UNSPSC
12352005
Target
ROR
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/ror-gamma-t-inverse-agonist-3.html
Concentration
10mM
Purity
99.92
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CC(C)C1=NC2=C(C=CC=C2OCC3=C(Cl)C=CC(S(=O)(N4CCC[C@H]4C(NC)=O)=O)=C3Cl)C(C5=CN=CN5C)=C1
Molecular Formula
C29H31Cl2N5O4S
Molecular Weight
616.56
References & Citations
[1]Amaudrut J, et al. Discovery of novel quinoline sulphonamide derivatives as potent, selective and orally active RORγ inverse agonists. Bioorg Med Chem Lett. 2019 Jul 15;29 (14) :1799-1806.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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