RORγt Inverse agonist 3

RORγt Inverse agonist 3 is a potent, selective and orally active RORγ inverse agonist, with EC50s of 0.22 μM and 0.15 μM for hRORγ and RORγt (human IL-17 cells), respectively[1].

Product Specifications

CAS Number

[2364429-77-4]

UNSPSC

12352005

Target

ROR

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/ror-gamma-t-inverse-agonist-3.html

Concentration

10mM

Purity

99.92

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CC(C)C1=NC2=C(C=CC=C2OCC3=C(Cl)C=CC(S(=O)(N4CCC[C@H]4C(NC)=O)=O)=C3Cl)C(C5=CN=CN5C)=C1

Molecular Formula

C29H31Cl2N5O4S

Molecular Weight

616.56

References & Citations

[1]Amaudrut J, et al. Discovery of novel quinoline sulphonamide derivatives as potent, selective and orally active RORγ inverse agonists. Bioorg Med Chem Lett. 2019 Jul 15;29 (14) :1799-1806.