2-O-Methylcytosine

2-O-Methylcytosine is an O-alkylated DNA adduct and is recognized as a damaged nucleobase. As an analogue of cytosine, it acts as a human endogenous metabolite. The presence of 2-O-Methylcytosine can alter the structural stability and base-pairing properties of DNA. The accumulation of such damaged nucleobases is closely linked to the induction of DNA mutations, which may result in various diseases, including cancer.