OPC-14523 dihydrochloride

OPC-14523 dihydrochloride is the dihydrochloride form of the free base OPC-14523. OPC-14523 dihydrochloride is an orally active dual agonist of sigma receptors and 5-HT1A receptors that also inhibits the 5-HT transporter, with IC50 values of 47/56 nM for sigma receptors σ1/2, 5-HT1A receptor IC50 = 2.3 nM, and 5-HT transporter IC50 = 80 nM. OPC-14523 dihydrochloride exhibits antidepressant-like activity. OPC-14523 dihydrochloride can be used in neuroscience research, including studies on antidepressants and neuroprotection.