F-14512 Hydrochloride
F-14512 Hydrochloride is a highly potent and tumor-selective inhibitor of DNA topoisomerase II. F-14512 Hydrochloride enhances topoisomerase II inhibition through the high affinity of polyamines for DNA, enabling selective cellular uptake. It exhibits significant cytotoxicity against tumor cells with high PTS activity and induces DNA damage and apoptosis. F-14512 Hydrochloride has demonstrated potent antitumor activity in various tumor models, including MX-1 breast cancer, HL-60 leukemia, and A2780 ovarian cancer. F-14512 Hydrochloride can be used in cancer treatment research.
Product Specifications
CAS Number
866874-39-7
Smiles
O=C1[C@]2 ([H]) [C@H] (C3=CC (OC) =C (C (OC) =C3) O) C4=CC (OCO5) =C5C=C4[C@H] ([C@@]2 ([H]) CO1) NC (CNCCCNCCCCNCCCN) =O.Cl.Cl.Cl.Cl
Molecular Formula
C33H51Cl4N5O8
Molecular Weight
787.60
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
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