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Phenamil methanesulfonate

Phenamil methanesulfonate is a potent analog of Amiloride that functions as a strong and less reversible epithelial sodium channel (ENaC) blocker with an IC50 of 400 nM, Phenamil methanesulfonate also acts as a competitive inhibitor of TRPP3 and suppressing TRPP3-mediated calcium transport with an IC50 of 140 nM in Ca2+ uptake assays. Phenamil methanesulfonate robustly activates BMP signaling to promote bone repair, supporting its use in cystic fibrosis lung disease, ion channel biology, and regenerative medicine research.

Product Specifications

CAS Number

1161-94-0

Purity

98.33% (May vary between batches)

Smiles

O=C (NC (=N) NC=1C=CC=CC1) C2=NC (Cl) =C (N=C2N) N.O=S (=O) (O) C

Molecular Formula

C13H16ClN7O4S

Molecular Weight

401.83

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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