Phenamil methanesulfonate
Phenamil methanesulfonate is a potent analog of Amiloride that functions as a strong and less reversible epithelial sodium channel (ENaC) blocker with an IC50 of 400 nM, Phenamil methanesulfonate also acts as a competitive inhibitor of TRPP3 and suppressing TRPP3-mediated calcium transport with an IC50 of 140 nM in Ca2+ uptake assays. Phenamil methanesulfonate robustly activates BMP signaling to promote bone repair, supporting its use in cystic fibrosis lung disease, ion channel biology, and regenerative medicine research.
Product Specifications
CAS Number
1161-94-0
Purity
98.33% (May vary between batches)
Smiles
O=C (NC (=N) NC=1C=CC=CC1) C2=NC (Cl) =C (N=C2N) N.O=S (=O) (O) C
Molecular Formula
C13H16ClN7O4S
Molecular Weight
401.83
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
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