RMC-4791
RMC-4791 is a RAS (ON) multi-selective tri-complex inhibitor (TCI) that binds the KRAS switch II region differently from daraxonrasib, with reduced dependence on the Y64 interaction. This enables RMC-4791 to retain inhibitory activity against KRAS Y64 resistance mutants and effectively suppress ERK signaling and cell proliferation, highlighting its potential to overcome daraxonrasib resistance.
Product Specifications
Smiles
C[C@H] (OC) C1=[C@@] ([C@@]2=C (CC (C) (C) COC ([C@H]3NN (C ([C@@H] (NC ([C@H] (C (C) C) N (C) C (C4 (CC4) C#N) =O) =O) CC5=CC6=CC (O) =C5) =O) CCC3) =O) C7=C (C=CC6=C7) N2CC) C=CC=N1
Molecular Formula
C48H59N7O7
Molecular Weight
846.04
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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