NEO-811
NEO-811 is a potent, selective, and cereblon (CRBN) -dependent E3 ubiquitin ligase-mediated proteolytic inhibitor that targets ARNT (HIF-1β) . NEO-811 blocks the ccRCC signaling pathway by degrading ARNT, thereby inhibiting the survival and proliferation of tumor cells. NEO-811 is suitable for use in studies of clear cell renal cell carcinoma (ccRCC) .
Product Specifications
CAS Number
3084635-77-5
Smiles
O[C@]1 (C (C) (C) CN (CC2=CC=C (C=C2) C=3N=CON3) CC1) C4=C (F) C5=C (C=C4) N=CC (=C5) C6C (=O) NC (=O) CC6
Molecular Formula
C30H30FN5O4
Molecular Weight
543.59
Storage Conditions
-20°C
Notes
For research use only.
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