P19As
P19As is a BCR-ABL PROTAC degrader based on Asciminib, with a DC50 of approximately 200 nM for the wild-type BCR-ABL protein. It is capable of degrading the T315I mutant and demonstrates strong antiproliferative activity in BaF3-BCR-ABL (T315I) cells. P19As is applicable for research in chronic myeloid leukemia and acute lymphoblastic leukemia.
Product Specifications
CAS Number
2635386-55-7
Smiles
O=C1C=2C (C (=O) N1C3C (=O) NC (=O) CC3) =CC=CC2NCCOCCOCCOCCN4C=C (CCCC (N[C@H]5CN (CC5) C6=C (C=C (C (NC7=CC=C (OC (Cl) (F) F) C=C7) =O) C=N6) C=8C=CNN8) =O) N=N4
Molecular Formula
C47H51ClF2N12O10
Molecular Weight
1017.45
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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