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PROTAC EML4-ALK Degrader-2

PROTACEML4-ALK Degrader-2 is an EML4-ALK PROTAC degrader. It demonstrates potent selective inhibitory activity against ALK with an IC50 of 1.6 nM. PROTACEML4-ALK also shows selectivity for IGF1R, INSR, FLT3, and FGFR2. Both in vitro and in vivo, PROTACEML4-ALK Degrader-2 exhibits anticancer properties. This compound is applicable in research related to non-small cell lung cancer (NSLC), lung cancer, and cervical cancer.

Product Specifications

CAS Number

2417174-28-6

Smiles

O=C1NC (=O) C (N2C (=O) C=3C=CC=C (NCCOCCOCCOCCNC (=O) CCN4CCC (C5=CC (OC (C) C) =C (C=C5C) NC6=NC=C (Cl) C (=N6) NC=7C=CC=CC7S (=O) (=O) C (C) C) CC4) C3C2=O) CC1

Molecular Formula

C52H66ClN9O11S

Molecular Weight

1060.66

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

Frequently Asked Questions

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