SIAIS056
SIAIS056 is a BCR-ABL PROTAC degrader with a DC50 value of 0.18 nM. It inhibits the BCR-ABL signaling pathway in a time-dependent manner in K562 cells and reduces the phosphorylation levels of BCR-ABL and its downstream molecules, STAT5 and CRKL. SIAIS056 can induce the degradation of various clinically relevant BCR-ABL resistant mutants and exhibits antiproliferative activity against K562 and 32D-BCR-ABL cells. Additionally, it can cause significant tumor regression in K562 xenograft models and is applicable for leukemia research.
Product Specifications
CAS Number
2378581-37-2
Smiles
O=C (NC=1C (Cl) =CC=CC1C) C=2SC (=NC2) NC=3N=C (N=C (C3) N4CCN (CCSC5=CC=CC=6C (=O) N (C (=O) C56) C7C (=O) NC (=O) CC7) CC4) C
Molecular Formula
C35H34ClN9O5S2
Molecular Weight
760.29
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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