SK5527

SK5527 is a selective AURKA PROTAC degrader that targets and degrades the AURKA protein, exhibiting a DC50 of 2 nM. It binds to NanoLuc-AURKA with an IC50 of 20 nM. In MYCN-amplified neuroblastoma cells, SK5527 effectively reduces MYCN levels, but its activity is constrained by MDR1-mediated efflux. In vivo, it efficiently lowers AURKA levels. SK5527 serves as a useful tool for neuroblastoma research.