PROTAC HDAC4 Degrader-1

PROTACHDAC4 Degrader-1 (compound SCT-1) is a potent and selective PROTACHDAC4 degrader. It effectively reduces HDAC4 protein levels, induces S phase cell cycle arrest, and inhibits colony formation, leading to the suppression of tumor cell proliferation. The compound has demonstrated inhibitory activity in the H460 mouse model and is applicable in cancer research, including studies of lung cancer.