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GNE-5472

GNE-5472 is a potent dual-function ERαPRRTAC degrader featuring an E3 ligase ligand that acts as a pan-IAP antagonist. By antagonizing cIAP1/2, GNE-5472 activates the non-canonical NF-κB pathway, resulting in a significant upregulation of TNFα expression. It inhibits the proliferation of breast cancer cells and induces apoptosis. GNE-5472 is applicable in breast cancer research.

Product Specifications

CAS Number

2417369-99-2

Smiles

C (=C (CC) C1=CC=CC=C1) (C2=CC=C (OCCN (C (CCOCCOCCC (NC3=NC (=C (NC (=O) [C@H]4N (C ([C@@H] (NC ([C@@H] (NC) C) =O) C5CCCCC5) =O) CCC4) S3) C6=CC=CC=C6) =O) =O) C) C=C2) C7=CC=C (O) C=C7

Molecular Formula

C59H73N7O9S

Molecular Weight

1056.33

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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