PROTAC BRD3 degrader-1

PROTACBRD3 degrader-1 (compound D072) is a potent and selective PROTACBRD3 degrader. It specifically degrades BRD3 in mice, leading to downregulation of H3K18ac expression without affecting BRD2 or BRD4. This compound reduces intraocular inflammation in an experimental autoimmune uveitis (EAU) mouse model and inhibits pro-inflammatory microglia in both uveitis retinas and LPS-treated mouse microglial cell line BV2. PROTACBRD3 degrader-1 is applicable for uveitis research.