Thymidine-d2
Thymidine-d2 is the deuterium labeled Thymidine. Thymidine, a specific precursor of deoxyribonucleic acid, is used as a cell synchronizing agent. Thymidine is a DNA synthesis inhibitor that can arrest cell at G1/S boundary, prior to DNA replication[1
Product Specifications
CAS Number
132376-92-2
Product Name Alternative
DThyd-d2; NSC 21548-d2
UNSPSC
12352005
Target
DNA/RNA Synthesis; Endogenous Metabolite; Isotope-Labeled Compounds; Orthopoxvirus
Type
Isotope-Labeled Compounds
Related Pathways
Anti-infection; Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Others
Applications
Cancer-programmed cell death
Field of Research
Cancer
Solubility
10 mM in DMSO
Smiles
O=C1N(C=C(C(N1)=O)C)[C@]2([H])O[C@@H]([C@H](C2)O)C([2H])([2H])O
Molecular Formula
C10H12D2N2O5
Molecular Weight
244.24
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.|[2]Chen G, et al. Cell Synchronization by Double Thymidine Block. Bio Protoc. 2018 Sep 5;8 (17) .; FIRKET H, et al. Autoradiographic visualization of synthesis of deoxyribonucleic acid in tissue culture with tritium-labelled thymidine. Nature. 1958 Jan 24;181 (4
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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