Azo-PROTAC-4C-trans

Azo-PROTAC-4C-trans is a BCR-ABL PROTAC degrader that efficiently targets BCR-ABL fusion proteins and ABL proteins. It exhibits strong, selective antiproliferative activity against K562 cells. The activity of Azo-PROTAC-4C-trans can be precisely and reversibly controlled through UV (for inactivation) /visible light (for activation) irradiation. This compound is applicable for myeloid leukemia research.