PROTAC HDAC8 Degrader-4

PROTACHDAC8 Degrader-3 (Compound BP6) is an efficient and selective HDAC8PROTAC degrader with low cytotoxicity, exhibiting a DC50 of 80 nM. It demonstrates IC50 values of 0.26 μM for HDAC8 and 30 μM for CRBN. PROTACHDAC8 Degrader-3 enhances Ac-SMC3 levels, stabilizes p53, and sensitizes cells to targeted agents such as Idasanutlin, indicating significant potential for combination therapy.