His-TERRα
His-TERRα is an ERRα PROTAC degrader. By using a single amino acid (His) as an E3 ligase ligand, His-TERRα leverages the N-end rule pathway to induce target protein degradation, markedly reducing molecular size and thus earning the designation mini-PROTAC. It significantly inhibits the proliferation and migration of MCF7 breast cancer cells and is useful for breast cancer research.
Product Specifications
CAS Number
2408835-49-2
Smiles
O (C1=C (C (F) (F) F) C=C (C#N) C=C1) C2=C (OC) C=C (C=C3C (=O) N (CC4=CN (CCCNC ([C@H] (CC5=CN=CN5) N) =O) N=N4) C (=O) S3) C=C2
Molecular Formula
C31H28F3N9O5S
Molecular Weight
695.68
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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