PROTAC HMGCR Degrader-2
PROTACHMGCR Degrader-2 is a PROTAC degrader targeting HMGCR with an IC50 of 0.25 μM. It effectively degrades HMGCR in Insig gene-silenced human liver cancer cells (HepG2) with a DC50 of 0.12 μM. This compound's oral prodrug is PROTACHMGCR Degrader-1. By utilizing the ubiquitin-proteasome system dependent on hypoxia-inducible factor prolyl hydroxylase (VHL), PROTACHMGCR Degrader-2 reduces cholesterol levels in HepG2 cells. It is applicable in hyperlipidemia-related research.
Product Specifications
CAS Number
2715104-46-2
Smiles
O (C (NCCCCCCCCCCC (N[C@H] (C (=O) N1[C@H] (C (NCC2=CC=C (C=C2) C3=C (C) N=CS3) =O) C[C@@H] (O) C1) C (C) (C) C) =O) =O) [C@@H]4[C@]5 (C (C=C[C@H] (C) [C@@H]5CC[C@H] (C[C@H] (CC (O) =O) O) O) =C[C@H] (C) C4) [H]
Molecular Formula
C53H79N5O10S
Molecular Weight
978.3
Storage Conditions
-20°C
Notes
For research use only.
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