Leu-PEG1-Dasa
Leu-PEG1-Dasa is a potent BCR-ABL PROTAC degrader with a DC50 of 0.48 nM. It employs a single amino acid as an E3 ligase ligand, categorizing it as a "mini-PROTAC, " and operates via the N-degron pathway. Leu-PEG1-Dasa exhibits strong antiproliferative activity against K562 cells and is applicable in chronic myelogenous leukemia (CML) research.
Product Specifications
CAS Number
3037776-72-7
Smiles
N (C1=CC (N2CCN (CCOC (CCOCCNC ([C@H] (CC (C) C) N) =O) =O) CC2) =NC (C) =N1) C=3SC (C (NC4=C (C) C=CC=C4Cl) =O) =CN3
Molecular Formula
C33H46ClN9O5S
Molecular Weight
716.3
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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