Gly-PEG3-BA
Gly-PEG3-BA is a PROTAC degrader that targets EML4-ALK. It effectively degrades the EML4-ALK protein in H3122 cells (EML4-ALK positive) with a DC50 of 0.50 μM. In H1975 cells (EGFRL858R/T790M double mutant), Gly-PEG3-BA significantly reduces the levels of the EGFR mutant (L858R/T790M) protein, with a DC50 of 20.15 μM. Additionally, Gly-PEG3-BA exhibits strong antiproliferative activity against H3122 cells and H1975 cells, with IC50 values of 0.84 μM and 20.74 μM, respectively. It is useful for research related to non-small cell lung cancer.
Product Specifications
CAS Number
3057939-66-6
Smiles
O=C (NCCOCCOCCOCCC (=O) N1CCN (C2=CC=C (NC3=NC=C (Cl) C (=N3) NC=4C=CC=CC4P (=O) (C) C) C (OC) =C2) CC1) CN
Molecular Formula
C34H48ClN8O7P
Molecular Weight
747.23
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
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