ZW-18-116

ZW-18-116 (compound 9) is a dual-target PROTAC degrader focusing on the oncogenic proteins TRKA and RET. It induces the degradation of TRKA and RET by recruiting the CRBN E3 ligase. ZW-18-116 shows potent antiproliferative activity in various cancer cell lines harboring RET or TRKA fusion genes. This compound is applicable to research on RET or TRKA-related cancers such as thyroid, lung, and colon cancers.