MS99-β-Gal
MS99-β-Gal (Gal-MS99) is a galactose-modified NPM-ALK PROTAC degrader. It is selectively hydrolyzed by SA-β-galactosidase (SA-β-gal) and esterases specifically in senescent cancer cells, releasing MS99, which targets the degradation of the NPM-ALK fusion protein. In senescent Karpas 299 cells, MS99-β-Gal has an IC50 value of 454.8 nM, significantly lower than its IC50 of 2.162 μM in normal Karpas 299 cells. This compound is applicable in cancer research.
Product Specifications
CAS Number
3055593-63-7
Smiles
O (C (C) =O) [C@@H]1[C@@H] (OC (C) =O) [C@@H] (OC (C) =O) [C@@H] (COC (C) =O) O[C@H]1OC2=CC=C (COC (O[C@H]3CN (C ([C@@H] (NC (CCCC (=O) N4CCC (CC4) C5=CC (OC (C) C) =C (NC=6N=C (NC7=C (S (C (C) C) (=O) =O) C=CC=C7) C (Cl) =CN6) C=C5C) =O) C (C) (C) C) =O) [C@H] (C (N[C@@H] (C) C8=CC=C (C=C8) C=9SC=NC9C) =O) C3) =O) C=C2
Molecular Formula
C78H96ClN9O20S2
Molecular Weight
1579.24
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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