SK4454

SK4454 is a selective AURKAPROTAC degrader that targets the AURKA protein with an IC50 of 8 nM. It binds to NanoLuc-AURKA with an IC50 of 20 nM. SK4454 effectively reduces MYCN levels in MYCN-amplified neuroblastoma cells, although its activity is limited by MDR1-mediated efflux. In vivo, SK4454 efficiently decreases AURKA levels. It is useful for research related to neuroblastoma.