PROTAC CDK6 Degrader 1

PROTACCDK6 Degrader 1 (compound 48a) is an effective and selective PROTAC CDK6 degrader with a DC50 of 0.037 μM. It shows selectivity for CDK4 with a DC50 greater than 10 μM. This compound induces G0/G1 phase cell cycle arrest and apoptosis by inhibiting the downstream signaling pathways of CDK6. In the MOLM-14 xenograft mouse model, PROTACCDK6 Degrader 1 reduces tumor burden and CDK6 levels. It is a valuable tool for researching CDK6-driven cancers, such as acute myeloid leukemia (AML) .