GPX4-IN-20

GPX4-IN-20 is a derivative of Arctigenin and acts as a molecular glue degrader of GPX4, inducing ferroptosis by increasing lipid ROS levels and inhibiting GSH levels. It reduces the protein expression and enzyme activity of GPX4 in a dose-dependent manner without affecting other ferroptosis-related proteins. GPX4-IN-20 promotes ubiquitin-dependent proteasomal degradation of GPX4 and elevates malondialdehyde (MDA) levels in HCT-116 cells. This compound is applicable in colorectal cancer research.