PROTAC AURKA degrader 2
PROTACAURKA degrader 2 (compound D) is a potent and selective degrader for PROTACAURKA, with an IC50 of 3.58 nM. It demonstrates 21.6 times greater selectivity for AURKA compared to AURKB (IC50 = 77.2 nM) and specifically depletes AURKA on the mitotic spindle.
Product Specifications
CAS Number
3093582-13-6
Smiles
O=C (NCCOCCOCCOCCOCCNC1=CC=CC=2C (=O) N (C (=O) C12) C3C (=O) NC (=O) CC3) C4=CC=C (C=C4OC) NC=5N=CC6=C (N5) C=7C=CC (Cl) =CC7C (=NC6) C=8C (F) =CC=CC8OC
Molecular Formula
C50H50ClFN8O11
Molecular Weight
993.44
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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