BION106
BION106 is a PROTAC degrader targeting dihydrofolate reductase-thymidylate synthase (DHFR-TS) . It exhibits potent antimalarial activity with a Ki value of 2.68 nM against Plasmodium falciparum and a toxicity of 0.2 μM. For mammalian cells, its Ki value exceeds 100 μM and the toxicity is 44.2 μM. BION106 is suitable for antimalarial research.
Product Specifications
CAS Number
3077918-44-3
Smiles
C (#N) [C@]1 ([C@H] ([C@H] (C (NC2=C (OC) C=C (C (NCCOCCOCCOCCNC (CCC3=C (OCCCOC=4C (CC) =NC (N) =NC4N) C=CC=C3) =O) =O) C=C2) =O) N[C@H]1CC (C) (C) C) C5=C (F) C (Cl) =CC=C5) C6=C (F) C=C (Cl) C=C6
Molecular Formula
C57H69Cl2F2N9O9
Molecular Weight
1133.13
Storage Conditions
-20°C
Notes
For research use only.
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